If this SPL incorporates inactivated NDCs listed because of the FDA initiated compliance action, They are going to be specified as a result.
Promethazine really should not be used by children young than 2 yrs because it may well induce significant (possibly deadly) sluggish/shallow breathing. This issue has transpired In spite of usual doses During this age group.
On the other hand, codeine must be administered only beneath shut supervision to patients having a background of drug abuse or dependence
Choose this medication by mouth. Adhere to the directions to the prescription label. You will take it with or without the need of food stuff. If it upsets your belly, consider it with foods. Use a specially marked spoon or container to evaluate Every single dose.
Head Damage And Amplified Intracranial Tension: The respiratory-depressant effects of narcotic analgesics and their potential to elevate cerebrospinal fluid tension could be markedly exaggerated during the presence of head harm, intracranial lesions or possibly a preexisting rise in intracranial pressure.
Codeine has excellent antitussive exercise, Though fewer than that of morphine at equal doses. It really is Utilized in choice to morphine, mainly because side effects are rare at the usual antitussive dose of codeine.
Use precisely as directed by your treatment team. Never just take over the advised dose. You might build tolerance to this medication if you take it for some time.
Postmarketing instances of respiratory melancholy, together with fatalities, have already been claimed with usage of promethazine hydrochloride in pediatric people fewer than two a long time of age. A wide array of fat-centered doses of promethazine hydrochloride have resulted in respiratory depression in these people.
These kids can be particularly sensitive to the respiratory depressant results of codeine that's been speedily metabolized to morphine. Codeine is contraindicated for write-up-operative pain administration in these clients (see WARNINGS – Loss of life Connected with Ultra-Speedy Metabolism of Codeine to Morphine and CONTRAINDICATIONS). Excessively massive dosages of antihistamines, which include promethazine hydrochloride, in pediatric individuals could induce sudden Loss of life (see OVERDOSAGE). Hallucinations and convulsions have transpired with therapeutic doses and overdoses of promethazine hydrochloride in pediatric patients. In pediatric clients who will be acutely unwell connected to dehydration, There's an increased susceptibility to dystonias with the usage of promethazine HCl.
Right before employing this medication, Females of childbearing age really should talk with their medical doctor(s) with regards to the hazards and benefits. Convey to your physician For anyone who is Expecting or Consider you may be pregnant. Through pregnancy, this medication is just not advisable. It may well a bit boost the hazard of start defects if made use of during the initial two months of pregnancy. Also, employing it for some time or in substantial doses close to the anticipated delivery date may possibly hurt the unborn little one.
DailyMed will supply notification of updates and additions to Drug Label information and facts at present shown on This great site via its RSS feed.
Most MAO inhibitors must also not be taken for two weeks in advance of remedy using this type of medication. Check with your medical doctor when to begin or prevent getting this medication.
Promethazine needs to be made use of cautiously in individuals with heart problems or with impairment of liver function.
If both medicines are prescribed together, your physician may possibly alter the dose Promethazine codeine syrup or how often you use 1 or both on the medicines.